The is a Japanese samurai clan which was at its peak one of the most powerful during the Muromachi and Sengoku periods (14th to 17th centuries). At its height, the clan had three main branches: the Ogigayatsu, Inukake, and Yamanouchi. Its most well-known member is the warlord Uesugi Kenshin (1530-1578).

During the Edo period, the Uesugi were a tozama or