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The yakalo is a cross of the yak (Bos grunniens) and the American bison (Bison bison, known as a buffalo in North America). It was produced by hybridisation experiments in the 1920s, when crosses were made between yak bulls and both pure bison cows and bison-cattle hybrid cows. As with many other inter-specific crosses, only female hybrids were found to be fertile (Haldane's rule).

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