Endo-polygalacturonase (, pectin depolymerase, pectolase, pectin hydrolase, and poly-?-1,4-galacturonide glycanohydrolase; systematic name (1->4)-?-D-galacturonan glycanohydrolase (endo-cleaving)) is an enzyme that hydrolyzes the ?-1,4 glycosidic bonds between galacturonic acid residues:

:(1,4-?-D-galacturonosyl)_n+m +