In organic chemistry sulfamation is the installation of either of two related functional groups, sulfamic acid (R₂NSO₃H) and sulfamate (R₂NSO₃^-). Typical methods entail reaction of primary amines with sources of sulfur trioxide such as pyridine-sulfur trioxide:
:RNH₂ + SO₃ -> RNHSO₃H

Sulfamation can